A neutral update on public “protocol” versions, supplement changes, and how these reports differ from proven cancer therapy.
Last updated: October 21, 2025
Background & protocol history
Joe Tippens first shared his story in 2017 after using veterinary fenbendazole alongside conventional therapy for lung cancer. His blog and interviews popularized what’s now called the “Joe Tippens protocol.”
Over time, the protocol’s composition and presentation have changed as new supplements were added and online communities formed around it. None of these versions have undergone formal clinical testing.
What’s new in 2025 versions
- Supplement bundles: Several online versions now include combinations of vitamin E, curcumin, CBD oil, and berberine. These are consumer-created additions—not verified updates by medical professionals.
- Presentation: Some sites label their bundle as “2025 protocol” or “revised protocol.” The core element (fenbendazole) and dosing claims remain anecdotal.
- Commercialization: More third-party sellers are packaging “protocol kits.” Always evaluate the source and regulatory compliance before purchase.
None of these changes are backed by peer-reviewed data or formal endorsement by oncology societies.
What hasn’t changed
- Evidence base: Still no completed human clinical trials proving efficacy.
- Regulatory status: Fenbendazole remains a veterinary drug not approved for humans.
- Mechanistic uncertainty: Preclinical results cannot be directly applied to people.
Scientific context & evidence
Recent reviews (2024–2025) still find no convincing human data showing benefit from fenbendazole in any cancer type. Preclinical signals exist but translation to clinical efficacy has not been demonstrated.
See our living review for citations and summaries: Fenbendazole & Cancer: Evidence (2025).
About supplements in the protocol
The protocol lists several non-prescription compounds (often vitamin E, curcumin, CBD, and berberine). These may affect drug metabolism or interact with chemotherapy or immunotherapy. Discuss all supplements with your oncologist before use.
Safety reminders
Fenbendazole’s human safety is not established. Potential risks include liver injury, drug interactions, and adulterated products. If you’re interested in repurposed drugs, see our guides below:
FAQs
What is the “Joe Tippens 2025 Protocol”?
It refers to updated versions of the anecdotal regimen Joe Tippens shared online using veterinary fenbendazole and supplements. No formal clinical testing or medical approval exists for this protocol.
Has the protocol been studied in human trials?
No. As of 2025, no completed randomized or controlled human trials show fenbendazole treats cancer effectively or safely.
What are the risks of following an unapproved protocol?
Unsupervised use can lead to liver injury, drug interactions, and delayed standard care. Always consult your oncology team first.
Why do “updates” appear online each year?
Most are community-driven variations or marketing rebrands. They don’t reflect new scientific evidence or official medical guidelines.
Overview •
Evidence Review •
Safety & Side Effects •
Legal Guide